Publications - Brian Luke lab

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Publications

2025

Wagner CB, Longaretti M, Sergi SG, Singh N, Tsirkas I, Bento F, Wong RP, Wilkens M, Hamperl S, Butter F, Aharoni A, Ulrich HD and Luke B (2025) Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict. Cell Rep, 44:116565.

Bento F, Longaretti M, Borges Pires V, Lockhart A and Luke B (2025) RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres. EMBO Rep, 26:3032-3044.

Gameiro E*, Juárez-Núñez KA*, Fung JJ, Shankar S, Luke B* and Khmelinskii A* (2025) Genome-wide conditional degron libraries for functional genomics. J Cell Biol, e202409007.

2024

Siametis A*, Stratigi K*, Giamaki D, Chatzinikolaou G, Akalestou-Clocher A, Goulielmaki E, Luke B, Schumacher B and Garinis GA (2024) Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence. Nat Commun, 5:4061.

2023

Nischwitz E*, Schoonenberg VAC*, Fradera-Sola A, Dejung M, Vydzhak O, Levin M, Luke B, Butter F# and Scheibe M# (2023) DNA damage repair proteins across the Tree of Life. iScience, 26:106778.

Pires V, Lohner N, Wagner T, Wagner C, Wilkens M, Hajikazemi M, Paeschke K, Butter F and Luke B (2023) RNA-DNA hybrids prevent resection at dysfunctional telomeres. Cell Rep, 42:112077.

Schindler N*, Tonn M*, Kellner V, Fung JJ, Lockhart A, Vydzhak O, Juretschke T, Möckel S, Beli P, Khmelinskii A and Luke B (2023) Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phase. Nat Commun, 14:1227.

2022

Guintini L*, Paillé A*, Graf M, Luke B, Wellinger RJ^# and Conconi A^# (2022) Transcription of ncRNAs promotes repair of UV induced DNA lesions in Saccharomyces cerevisiae subtelomeres. PLOS Genet, 18:e1010167.

Kissling VM, Reginato G*, Bianco E*, Kasaciunaite K, Tilma J, Cereghetti G, Schindler N, Lee SS, Guérois R, Luke B, Seidel R, Cejka P^# and Peter M^# (2022) Mre11-Rad50 oligomerization promotes DNA double-strand break repair. Nat Commun, 13:2374.

Li L, Wang J, Yang Z, Zhao Y, Jiang H, Jiang L, Hou W, Ye R, He Q, Kupiec M, Luke B, Cao Q, Qi Z, Li Z and Lou H (2022) Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint. EMBO J, 41:e108290.

Misino S, Busch A, Wagner C, Bento F and Luke B (2022) TERRA increases at short telomeres in yeast survivors and regulates survivor associated senescence (SAS). Nucleic Acids Res, 50:12829–12843.

Pérez-Martínez L, Wagner T and Luke B (2022) Telomere interacting proteins and TERRA regulation. Front Genet, 13:872636.

Spada S, Luke B and Danckwardt S (2022) The bidirectional link between RNA cleavage and polyadenylation and genome stability: recent insights from a systematic screen. Front Genet, 13:854907.

2021

Mosler T, Conte F, Longo GMC, Mikicic I, Kreim N, Möckel MM, Petrosino G, Flach J, Barau J, Luke B, Roukos V and Beli P (2021) R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun, 12:7314.

Wagner T, Pérez-Martínez L, Schellhaas R, Barrientos-Moreno M, Öztürk M, Prado F, Butter F and Luke B (2021) Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence. PLOS Genet, 16:e1008603.

2020

Niehrs C* and Luke B* (2020) Regulatory R-loops as facilitators of gene expression and genome stability. Nat Rev Mol Cell Biol, 21:167–178.

Pérez-Martínez L, Öztürk M, Butter F^# and Luke B^# (2020) Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence. EMBO Rep, 21:e49087.

Vydzhak O*, Bender K*, Klermund J, Busch A, Reimann S and Luke B (2020) Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents. DNA Repair, 95:102939.

Vydzhak O, Luke B and Schindler N (2020) Non-coding RNAs at the eukaryotic rDNA locus: RNA-DNA hybrids and beyond. J Mol Biol, 432:4287–4304.

2019

Jolivet P, Serhal K, Graf M, Eberhard S, Xu Z, Luke B and Teixeira MT (2019) A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae. Sci Rep, 9:1845.

Kellner V^# and Luke B^# (2019) Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair. EMBO J, 39:e102309.

Lockhart A, Pires VB, Bento F, Kellner V, Luke-Glaser S, Yakoub G, Ulrich HD and Luke B (2019) RNase H1 and H2 are differentially regulated to process RNA-DNA hybrids. Cell Rep, 29:2890–2900.e5.

Schmidt TT, Sharma S, Reyes GX, Kolodziejczak A, Wagner T, Luke B, Hofer A, Chabes A and Hombauer H (2019) Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio. Nucleic Acids Res, 48:264–277.

2018

Luke B (2018) Telomere regulation. Differentiation, 102:27–29 [guest editor of the issue].

Michelini F, Jalihal AP, Francia S, Meers C, Neeb ZT, Rossiello F, Gioia U, Aguado J, Jones-Weinert C, Luke B, Biamonti G, Nowacki M, Storici F, Carninci P, Walter NG and d’Adda di Fagagna F (2018) From “cellular” RNA to “smart” RNA: Multiple roles of RNA in genome stability and beyond. Chem Rev, 118:4365–4403.

Misino S, Bonetti D, Luke-Glaser S and Luke B (2018) Increased TERRA levels and RNase H sensitivity are conserved hallmarks of post-senescent survivors in budding yeast. Differentiation, 100:37–45.

2017

Graf M*, Bonetti D*, Lockhart A*, Serhal K, Kellner V, Maicher A, Jolivet P, Teixeira MT and Luke B (2017) Telomere length determines TERRA and R-loop regulation through the cell cycle. Cell, 170:72–85.

Lafuente-Barquero J, Luke-Glaser S, Graf M, Silva S, Gómez-González B, Lockhart A, Lisby M, Aguilera A and Luke B (2017) The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. PLOS Genet, 13:e1007136.

2016

Buser R*, Kellner V*, Melnik A, Wilson-Zbinden C, Schellhaas R, Kastner L, Piwko W, Dees M, Picotti P, Maric M, Labib K, Luke B^# and Peter M^# (2016) The replisome-coupled E3 ubiquitin ligase Rtt101^Mms22 counteracts Mrc1 function to tolerate genotoxic stress. PLOS Genet, 12:e1005843.

Dieckmann AK, Babin V, Harari Y, Eils R, König R, Luke B^# and Kupiec M^# (2016) Role of the ESCRT complexes in telomere biology. MBio, 7:e01793-16.

Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, Luke B, Muzi-Falconi M, Myers CL, Mitra RD, Shore D, Brown GW, Zhang Z, Boone C and Andrews BJ (2016) Exploring quantitative yeast phenomics with single-cell analysis of DNA damage foci. Cell Syst, 3:264–277.e10.

Poos AM, Maicher A, Dieckmann AK, Oswald M, Eils R, Kupiec M, Luke B and König R (2016) Mixed integer linear programming based machine learning approach identifies regulators of telomerase in yeast. Nucleic Acids Res, 44:e93.

Silva S, Altmannova V, Luke-Glaser S, Henriksen P, Gallina I, Yang X, Choudhary C, Luke B, Krejci L and Lisby M (2016) Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes Dev, 30:700–717.

2015

Feuerhahn S, Chen L, Luke B^# and Porro A^# (2015) No DDRama at chromosome ends: TRF2 takes centre stage. Trends Biochem Sci, 40:275–285.

Rippe K^# and Luke B^# (2015) TERRA and the state of the telomere. Nat Struct Mol Biol, 22:853–858.

Stockklausner C*, Raffel S*, Klermund J, Bandapalli OR, Beier F, Brümmendorf TH, Bürger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B^#, Trumpp A^# and Kulozik AE^# (2015) A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging, 7:911–927.

2014

Balk B, Dees M, Bender K and Luke B (2014) The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation. RNA Biol, 11:95–100.

Klermund J, Bender K and Luke B (2014) High nutrient levels and TORC1 activity reduce cell viability following prolonged telomere dysfunction and cell cycle arrest. Cell Rep, 9:324–335.

Maicher A, Lockhart A and Luke B (2014) Breaking new ground: Digging into TERRA function. Biochim Biophys Acta – Gene Regul Mech, 1839:387–394.

2013

Balk B*, Maicher A*, Dees M, Klermund J, Luke-Glaser S, Bender K and Luke B (2013) Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence. Nat Struct Mol Biol, 20:1199–1205.

2012

Luke-Glaser S and Luke B (2012) The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast. PLOS One, doi: 10.1371/journal.pone.0042028.

Luke-Glaser S, Poschke H and Luke B (2012) Getting in (and out of) the loop: Regulating higher order telomere structures. Front Oncol, 2:180.

Maicher A, Kastner L, Dees M and Luke B (2012) Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res, 40:6649–6659.

Maicher A*, Kastner L* and Luke B (2012) Telomeres and disease: Enter TERRA. RNA Biol, 9:843–849.

Poschke H*, Dees M*, Chang M, Amberkar S, Kaderali L, Rothstein R and Luke B (2012) Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast. PLOS Genet, 8:e1002960.